2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140910
    Biotin-PEG4-azide 1309649-57-7 99.75%
    Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-azide
  • HY-B0704
    Azelaic acid 123-99-9 98.0%
    Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals.
    Azelaic acid
  • HY-140922
    Biotin-PEG4-alkyne 1458576-00-5 99.65%
    Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG4-alkyne
  • HY-141167A
    TCO-PEG4-NHS ester 1621096-79-4 99.16%
    TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG4-NHS ester
  • HY-40171
    NH2-C2-NH-Boc 57260-73-8 99.97%
    NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-C2-NH-Boc
  • HY-140765
    Azido-PEG4-NHS-ester 1807534-82-2 98.02%
    Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-NHS-ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-NHS-ester
  • HY-30105
    N-Boc-piperazine 57260-71-6 99.99%
    N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).
    N-Boc-piperazine
  • HY-42776
    NH2-PEG3-C2-NH-Boc 101187-40-0 99.88%
    NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-NH-Boc
  • HY-126887
    Mal-PEG8-NHS ester 2055033-05-9 98.96%
    Mal-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG8-NHS ester
  • HY-30843
    2-Boc-2,6-Diazaspiro[3.3]heptane 1041026-70-3 99.95%
    2-Boc-2,6-Diazaspiro[3.3]heptane is a PROTAC linker that can be used in the synthesis of PROTACs.
    2-Boc-2,6-Diazaspiro[3.3]heptane
  • HY-140335
    Alkynyl myristic acid 82909-47-5
    Alkynyl myristic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Alkynyl myristic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkynyl myristic acid
  • HY-W008574A
    TGN-020 sodium 1313731-99-5 99.96%
    TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats.
    TGN-020 sodium
  • HY-W000434
    Fmoc-NH-PEG4-CH2CH2COOH 557756-85-1 99.64%
    Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG4-CH2CH2COOH
  • HY-140341
    Sulfo-NHS-Acetate 152305-87-8 98.0%
    Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Sulfo-NHS-Acetate
  • HY-128834
    N3-PEG4-C2-NH2 951671-92-4 ≥98.0%
    N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N3-PEG4-C2-NH2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-PEG4-C2-NH2
  • HY-151716
    Halo-DBCO 1808119-16-5 98.25%
    Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples.
    Halo-DBCO
  • HY-130283
    Methyltetrazine-Ph-NHS ester 1644644-96-1 98.94%
    Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-Ph-NHS ester
  • HY-140452
    Azido-PEG2-C2-acid 1312309-63-9 99.88%
    Azido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-acid
  • HY-140214
    Azido-PEG5-amine 516493-93-9 98.0%
    Azido-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-amine
  • HY-W008474
    Boc-NH-PEG2-C2-NH2 153086-78-3 99.38%
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-C2-NH2
PROTAC Linkers Isoform Comparison

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